Wei Hua Chen, 50302 Orchard Ln, Chapel Hill, NC 27514

7624054, Nov 24, 2009

Aug 25, 2005

11/211353

Wei Chen - Apex NC, US
Donald J. Erdman - Raleigh NC, US
Ping Hu - Cary NC, US

SAS Institute Inc. - Cary NC

G06Q 40/00

705 35, 705 36 R, 705 37

Systems and methods for optimizing financial risk mitigations. A system and method can be provided for the generation of a financial risk mitigation optimization model. The model can be used in determining an allocation of financial risk mitigations with respect to exposures.

2009026, Oct 22, 2009

Dec 14, 2006

12/097697

Wei Chen - Chapel Hill NC, US
Lawrence S. Barak - Durham NC, US
Marc G. Caron - Hillsborough NC, US
Robert Lefkowitz - Durham NC, US

A61K 51/00
C12Q 1/48
A61K 49/00

424 111, 435 15, 424 91

The invention relates to a screening method for the Smoothened receptor for testing compositions as potential Smoothened receptor ligands, either agonist or antagonist activity, by use of an arrestin-reporter molecule conjugate. It also relates to testing cells and individuals by administering a smoothened receptor ligand-reporter molecule conjugate and observing locations where the ligand binds and then using an increased number of surface Smoothened receptors compared to a pre-established criteria as an indication of a cancerous growth or tumor.

2011015, Jun 23, 2011

Dec 17, 2009

12/640881

Zhiping Yang - Cary NC, US
Donald James Erdman - Raleigh NC, US
Wei Chen - Apex NC, US

G06N 5/02
G06F 17/10

706 47, 706 58, 703 2

Computer-implemented systems and methods are provided for implementing a dynamic model switching simulator that generates a plurality of simulations. A system and method generates a simulation comprising predictions over a plurality of time periods. Generating a simulation includes generating a first time period prediction using a first model of a first model type. Generating the plurality of subsequent time period predictions includes evaluating the model switching rule to identify whether to switch models for a subsequent time period prediction, generating the subsequent time period prediction using the first model if a switch of models is not identified, and generating the subsequent time period prediction using a second model of a second model type otherwise.

2011016, Jul 7, 2011

Jan 6, 2010

12/683020

Zhiping Yang - Cary NC, US
Donald James Erdman - Raleigh NC, US
Stacey Michelle Christian - Cary NC, US
Wei Chen - Apex NC, US

G06Q 40/00

705 36 R, 705 38

Computer-implemented systems and methods are provided for generating a simulated forecast based on members of a pool of input risk factor variables. Certain members of the pool of input risk factor variables are identified as members of a first set of variables, and certain other members of the pool of input risk factor variables are identified as members of a second set of variables. A first simulation is generated via a first simulation method using the first set of variables, and a second simulation is generated via a second simulation method that differs from the first simulation method using the second set of variables. The first simulation and the second simulation are generated using correlations among variables in the first set of variables and variables in the second set of variables.

2011021, Sep 1, 2011

Mar 1, 2010

12/714984

Keith Eugene Crowe - Cary NC, US
Stacey Michelle Christian - Cary NC, US
Wei Chen - Apex NC, US

G06Q 40/00

705 37, 705 35

Systems and methods for determining a future conversion curve between a first metric and a second metric are provided. A system and method can include receiving a first metric and a second metric. A plurality of conversion curves are retrieved, where each conversion curve has a corresponding weight. One or more paths between the first metric and the second metric are calculated using two or more conversion curves, where each path begins with the first metric and ends with the second metric, and where each path is associated with a path weight based upon the sum of the weights used to calculate the path. A shortest path between the first metric and the second metric is determined, where the shortest path is the path having the least weight, and a future conversion curve is generated by collapsing the two or more conversion curves of the shortest path.

2011023, Sep 29, 2011

Jun 16, 2009

12/999922

Wei Chen - Chapel Hill NC, US
Lawrence S. Barak - Durham NC, US
Jiangbo Wang - Durham NC, US
Robert J. Lefkowitz - Durham NC, US
Herbert Kim Lyerly - Chapel Hill NC, US

G01N 23/00

435 72

The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression.

2012009, Apr 19, 2012

Jun 16, 2009

12/737044

Wei Chen - Durham NC, US
Lawrence Barak - Durham NC, US
H. Kim Lyerly - Durham NC, US
Jiangbo Wang - Durham NC, US

A61K 31/454
A61K 31/5377
A61K 31/55
A61K 31/553
A61P 35/00
A61K 31/551
A61K 31/4545
A61K 31/426
A61K 31/4439
A61K 31/538
A61K 31/506
A61K 31/4725

51421021, 51425218, 51425214, 5142355, 514318, 51421704, 51421115, 514307, 514218, 514365, 514342, 5142305

The present invention relates, in general, to the Smoothened receptor and, in particular, to a method of modulating Smoothened receptor activity and to compounds and compositions suitable for use in such a method.

2013000, Jan 3, 2013

Sep 21, 2010

13/497364

Wei Chen - Chapel Hill NC, US
Minyong Chen - Durham NC, US
H. Kim Lyerly - Chapel Hill NC, US
Lawrence S. Barak - Durham NC, US
Robert Mook - Chapel Hill NC, US
Takuya Osada - Chapel Hill NC, US
Michael A. Morse - Raleigh NC, US

A61K 31/167
G01N 33/574
A61P 9/00
C12Q 1/68
A61K 31/277
A61K 31/18

514521, 514622, 514617, 514604, 514619, 435 611, 435 723, 435 71, 435 612, 435 792, 436501

Methods of treating Wnt/Frizzled-related diseases, comprising administering niclosamide compounds are provided. Methods of predicting whether a disease will respond to treatment with a niclosamide compound are also provided.