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Wensheng Liu26 Village Rd, Kendall Park, NJ 08824

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26 Village Rd, Kendall Park, NJ 08824    732-9406606   

Minneapolis, MN   

Piscataway, NJ   

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Us Patents

Prolylcarboxypeptidase Inhibitors

US Patent:
8569299, Oct 29, 2013
Filed:
Jun 3, 2011
Appl. No.:
13/702622
Inventors:
Thomas H. Graham - Scotch Plains NJ, US
Wensheng Liu - Edison NJ, US
Iyassu K. Sebhat - Jersey City NJ, US
Zhi-Cai Shi - Monmouth Junction NJ, US
Assignee:
Merck Sharp & Dohme Corp - Rahway NJ
International Classification:
A61K 31/5377
A61K 31/454
C07D 413/14
C07D 401/02
C07D 401/14
US Classification:
5142365, 514326, 544130, 546210, 546211
Abstract:
Compounds of structural formulas I-1 and I-2 are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.

Method And Apparatus For Impulse Noise Detection And Suppression For Dvb-T

US Patent:
2009016, Jul 2, 2009
Filed:
Dec 26, 2007
Appl. No.:
11/964373
Inventors:
Wensheng V. Liu - Pennington NJ, US
Devan Namboodiri - Holland PA, US
Assignee:
ADVANCED MICRO DEVICES, INC. - Sunnyvale CA
International Classification:
H03D 1/04
US Classification:
375346
Abstract:
A method and apparatus for adaptive impulse noise detection and suppression (INDS) where information regarding detected impulse noise (IN) pulses is used to adjust detection and suppression parameters. To decrease the rate of false detection, groups of samples, instead of individual samples, of the digitized received signal are used to detect the presence of IN pulses. The method and apparatus for adaptive INDS may be used in communication systems employing single-carrier or multi-carrier modulation schemes, and is preferably used for Orthogonal Frequency Division Multiplexing (OFDM) modulation. The proposed adaptive INDS systems may be used to effectively reduce the effects of impulse noise and improve the quality of received signals.

Spirocyclic Hetercycle Compounds Useful As Hiv Integrase Inhibitors

US Patent:
2016031, Nov 3, 2016
Filed:
Dec 17, 2014
Appl. No.:
15/105376
Inventors:
Thomas H. Graham - Scotch Plains NJ, US
Wensheng Liu - Edison NJ, US
Tao Yu - Edison NJ, US
Yonglian Zhang - Metuchen NJ, US
Sherman T. Waddell - Westfield NJ, US
John S. Wai - Harleysville PA, US
Paul J. Coleman - Harleysville PA, US
John M. Sanders - Hatfield PA, US
Mark W. Embrey - Harleysville PA, US
Abbas M. Walji - Lansdale PA, US
Christine Ng Di Marco - Conshohocken PA, US
Thomas G. Steele - Schwenksville PA, US
Lihong Hu - Shanghai, CN
Xuanjia Peng - Shanghai, CN
Assignee:
MERCK SHARP & DOHME CORP. - RAHWAY NJ
International Classification:
A61K 31/53
A61K 45/06
C07D 471/22
A61K 31/675
C07D 491/20
A61K 31/55
A61K 31/499
C07F 9/6561
C07D 471/20
C07D 495/20
Abstract:
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

4-Pyridinonetriazine Derivatives As Hiv Integrase Inhibitors

US Patent:
2015032, Nov 19, 2015
Filed:
Dec 12, 2013
Appl. No.:
14/652580
Inventors:
- Rahway NJ, US
Thomas H. Graham - Scotch Plains NJ, US
Abbas Walji - Lansdale PA, US
Sherman T. Waddell - Wesetfield NJ, US
Tao Yu - Edison NJ, US
Yonglian Zhang - Metuchen NJ, US
Wensheng Liu - Edison NJ, US
Paul J. Coleman - Harleysville PA, US
John Wai - Harleysville PA, US
Thomas Steele - Schwenksville PA, US
Christina Di Marco - Lafayette Hill PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 471/04
C07D 471/10
C07D 471/20
A61K 45/06
A61K 31/675
C07D 471/14
A61K 31/55
A61K 31/4985
A61K 31/53
C07F 9/6521
Abstract:
The present invention relates to 4-Pyridinonetriazine Derivatives of Formula (I); and pharmaceutically acceptable salts thereof, wherein A, X, Y, R, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one 4-Pyridinonetriazine Derivative, and methods of using the 4-Pyridinonetriazine Derivatives for treating or preventing HIV infection in a subject.

Isbn (Books And Publications)

Shortest Paths For Sub-Riemannian Metrics On Rank-Two Distributions

Author:
Wensheng Liu
ISBN #:
0821804049

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