Inventors:
Thomas H. Graham - Scotch Plains NJ, US
Wensheng Liu - Edison NJ, US
Tao Yu - Edison NJ, US
Yonglian Zhang - Metuchen NJ, US
Sherman T. Waddell - Westfield NJ, US
John S. Wai - Harleysville PA, US
Paul J. Coleman - Harleysville PA, US
John M. Sanders - Hatfield PA, US
Mark W. Embrey - Harleysville PA, US
Abbas M. Walji - Lansdale PA, US
Christine Ng Di Marco - Conshohocken PA, US
Thomas G. Steele - Schwenksville PA, US
Lihong Hu - Shanghai, CN
Xuanjia Peng - Shanghai, CN
Assignee:
MERCK SHARP & DOHME CORP. - RAHWAY NJ
International Classification:
A61K 31/53
A61K 45/06
C07D 471/22
A61K 31/675
C07D 491/20
A61K 31/55
A61K 31/499
C07F 9/6561
C07D 471/20
C07D 495/20
Abstract:
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.