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Yili U Chen, 4939 Magnolia Way, Chadds Ford, PA 19317

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Chadds Ford, PA   

1349 Wooded Knls, West Chester, PA 19382    610-7931989   

O Fallon, MO   

Newark, DE   

Houston, TX   

Chesterfield, MO   

Ann Arbor, MI   

Dublin, OH   

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Yili Chen

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Us Patents

Bicyclic Heterocyclic Compounds As Pde2 Inhibitors

US Patent:
2018014, May 24, 2018
Filed:
Jun 27, 2016
Appl. No.:
15/736202
Inventors:
Shawn J. STACHEL - West Point PA, US
Christopher J. SINZ - Rahway NJ, US
Yili CHEN - Rahway NJ, US
Jonathan E. WILSON - Rahway NJ, US
Michael P. DWYER - Rahway NJ, US
Daniel V. PAONE - Lansdale PA, US
Shimin XU - Beijing, CN
- Rahway NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 487/04
A61P 25/18
A61P 25/22
A61P 25/28
A61P 25/06
A61P 25/16
Abstract:
The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

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