Zheng W Zhang, 55Oklahoma City, OK

7989851, Aug 2, 2011

Nov 16, 2006

11/600556

Yicheng Lu - East Brunswick NJ, US
Ying Chen - Piscataway NJ, US
Zheng Zhang - Belle Mead NJ, US

Rutgers, the State University of New Jersey - New Brunswick NJ

H01L 29/82
H03H 9/56

257252, 257 79, 257253, 257414, 257E23165, 257E29081, 257E29093, 257E33005, 257E5104, 310313 A, 310313 B, 310313 R, 333133, 333187

The present invention provides the multifunctional biological and biochemical sensor technology based on the integration of ZnO nanotips with bulk acoustic wave (BAW) devices, particularly, quartz crystal microbalance (QCM) and thin film bulk acoustic wave resonator (TFBAR). ZnO nanotips provide giant effective surface area and strong bonding sites. Furthermore, the controllable wettability of ZnO nanostructured surface dramatically reduces the liquid consumption and enhances the sensitivity of the biosensor device.

2012005, Mar 1, 2012

Jul 28, 2011

13/193057

Yicheng Lu - East Brunswick NJ, US
Ying Chen - Piscataway NJ, US
Zheng Zhang - Belle Mead NJ, US

Rutgers, The State University of New Jersey - New Brunswick NJ

G01N 30/96
H01L 41/04

422 69, 310340

The present invention provides the multifunctional biological and biochemical sensor technology based on the integration of ZnO nanotips with bulk acoustic wave (BAW) devices, particularly, quartz crystal microbalance (QCM) and thin film bulk acoustic wave resonator (TFBAR). ZnO nanotips provide giant effective surface area and strong bonding sites. Furthermore, the controllable wettability of ZnO nanostructured surface dramatically reduces the liquid consumption and enhances the sensitivity of the biosensor device.

2006005, Mar 16, 2006

Apr 29, 2005

11/119475

Yicheng Lu - East Brunswick NJ, US
Zheng Zhang - Bellemead NJ, US
Nuri Emanetoglu - Woodbury NJ, US
Masayori Inouye - New Brunswick, JP
Oleg Mirochnitchenko - East Brunswick NJ, US

C12Q 1/68
H01L 29/82

257252000, 435006000

The present invention provides the multifunctional biological and biochemical sensor technology based on ZnO nanostructures. The ZnO nanotips serve as strong DNA or protein molecule binding sites to enhance the immobilization. Patterned ZnO nanotips are used to provide conductivity-based biosensors. Patterned ZnO nanotips are also used as the gate for field-effect transistor (FET) type sensors. Patterned ZnO nanotips are integrated with SAW or BAW based biosensors. These ZnO nanotip based devices operate in multimodal operation combining electrical, acoustic and optical sensing mechanisms. The multifunctional biosensors can be arrayed and combined into one biochip, which will enhance the sensitivity and accuracy of biological and biochemical detection due to strong immobilization and multimodal operation capability. Such biological and biochemical sensor technology are useful in detection of RNA-DNA, DNA-DNA, protein-protein, protein-DNA and protein-small molecules interaction. It can be further applied for drug discovery, and for environmental monitoring and protection.

2005011, Jun 2, 2005

Jun 6, 2003

10/456050

Yicheng Lu - East Brunswick NJ, US
Zheng Zhang - Bellemead NJ, US
Nuri Emanetoglu - Woodbury NJ, US
Masayori Inouye - New Brunswick NJ, US
Oleg Mirochnitchenko - East Brunswick NJ, US

H01L029/84

257252000

The present invention provides the multifunctional biological and biochemical sensor technology based on ZnO nanostructures. The ZnO nanotips serve as strong DNA or protein molecule binding sites to enhance the immobilization. Patterned ZnO nanotips are used to provide conductivity-based biosensors. Patterned ZnO nanotips are also used as the gate for field-effect transistor (FET) type sensors. Patterned ZnO nanotips are integrated with SAW or BAW based biosensors. These ZnO nanotip based devices operate in multimodal operation combining electrical, acoustic and optical sensing mechanisms. The multifunctional biosensors can be arrayed and combined into one biochip, which will enhance the sensitivity and accuracy of biological and biochemical detection due to strong immobilization and multimodal operation capability. Such biological and biochemical sensor technology are useful in detection of RNA-DNA, DNA-DNA, protein-protein, protein-DNA and protein-small molecules interaction. It can be further applied for drug discovery, and for environmental monitoring and protection.